Hello, welcome...
Do you have a close relative who is a Canadian citizen or PR?
Do you plan on moving to Canada and working there, as in getting a job? Do you have a few hundred thousand dollars to spare? (It's a honest question that determines your category).
You cannot get citizenship until you've had a PR for I think 3 years. So that comes first. There's only a few ways to get PR without a close Canadian relative. And sorry, no matter what you think of the US, we don't qualify as refugees.

Start at the CIC page. If you go for skilled worker, you and your wife should both take the point test to start. Then if you make the cut, download all the app documents and be sure to download the Buffalo office specific requirements (the Buffalo office checklist is where all the hard stuff is). I wouldn't try calling CIC. They are not there to help you.
I'm sort of gathering documents, but I've had an "interesting" life. Canada apparently doesn't want that. Can you list every address you've lived at, and everything you've been doing, since you were 18? Leave no gaps! Man, I've lived off state lands, in hostels, let alone a bunch of dorms, apartments, and houses across 15 states. I've attended 7 universities, and held as many jobs. Now, I've got a masters degree, 10 years job experience, and speak english, have the $10K, etc. so I make the cut theoretically. So there's hope, if I ever get around to getting this all together. Though job prospects there for me aren't good, so I've sort of back-burnered the whole thing for now.
Anyway, I'd be glad to chat with you about what little I know, you can PM me. Do understand this is a long process. I'd figure 2-6 months to gather the paperwork, and 18 months to file if you do everything perfect. It's frustrating and expensive.
If you can't move there, you'll become freakishly addicted to Canadian web sites and news and such, and you'll have a lot of nice vacations to Canada.
